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Programmed cell death (PCD) is a dominant process, which forms part of the core of the complete growth of eukaryotes and plays a regulatory role in NAFLD (15), including apoptosis, necroptosis, autophagy, entosis, paraptosis, pyroptosis, etc

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Becatti M, Fucci R, Mannucci A, et al

Despite the short plasma half-life, downstream biological effects in tissue persist substantially longer, consistent with a signaling cascade rather than direct dose-response activity